Biofilm Control via Phytochemicals - A Review

Increasing antimicrobial resistance worldwide is major health concern, this is due to frequent use of antibiotic and resistance within individual due to extensive use of antibiotic. And thus infectious disease are almost untreatable by normal diagnosis. Mostly limited spectrum of antibiotics is leads to formation of biofilm which is currently contributes to about 80% of human infection because sessile state of bacteria is protected against antimicrobial treatment than its planktonic state. So secondary metabolites from plant is recognized as a pharmaceutically active products, again various classes of phytochemical shown antimicrobial activity against pathogenic microbes so it bears capacity to reduce disease. 

- Taherabbas Sathiya

Introduction 

Now a days the prevalence of antimicrobial resistance is salient feature for food industry and even researchers also, because the increasing use of antibiotics for treatment of disease is indiscriminate per se. and ultimately the conventional antibiotics are ineffective to cure infectious disease and it’s relating to formation of biofilm. And researchers reported that over 80% infection in human are caused by biofilm because this sessile state of bacteria is protected against the antimicrobial treatment. And out of this all problem we have to find a new approach to overcome such circumstances and phytochemical is one of them. And they found that several biofilm classes are important to restrict the growth of clinical pathogenic microorganism because this phytochemical bearing the capability to reduce disease to acceptable level.

Biofilm and antimicrobial resistance

As we seen the current use of antibiotics is major concern for to treat various disease because it leads to increase antimicrobial resistance (10-100 times as compared to its planktonic counterpart) because both of the planktonic and sessile part bearing different physiology and even gene expression morphology also. The main cause is either due to inadequate therapeutic strategies or transmission of disease within and between individual.